UNC80

Across TCGA patient cohorts, UNC80 mutation is significantly associated with the RNA expression of many other genes, with 5,558 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UNC80-associated genes across cancer lineages are OGFOD1, NPM1, and HIRIP3. Each is linked with UNC80 in more than 4 cancer types. Because this analysis shows association rather than direction, both UNC80-to-partner and partner-to-UNC80 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OGFOD1 grouped by UNC80-low versus UNC80-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UNC80→partner) and Y-score (partner→UNC80) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	OGFOD1 →	+0.279	+1.232	<.001	<.001	3	5
COAD	NPM1 →	+0.339	+1.754	.003	<.001	3	5
LUSC	HIRIP3 →	+0.631	+3.229	.003	.009	3	4
UCEC	CWC27 →	+0.307	+1.595	.001	.001	3	4
UCEC	NUS1 →	+0.354	+1.191	<.001	.009	3	4
READ	PPP2R5E →	+0.569	+3.377	<.001	.003	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,558 associations by consensus.

OGFOD1 by UNC80 expression — UCEC

Explore this box plot interactively →