UNC80

Across TCGA patient cohorts, UNC80 mutation is significantly associated with the total protein of many other genes, with 65 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UNC80-associated genes across cancer lineages are TIGAR, MIG-6, and Caspase-7-cleavedD198. Each is linked with UNC80 in more than 4 cancer types. Because this analysis shows association rather than direction, both UNC80-to-partner and partner-to-UNC80 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIGAR grouped by UNC80-low versus UNC80-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UNC80→partner) and Y-score (partner→UNC80) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TIGAR →	+0.089	+1.348	.016	<.001	3	5
COAD	MIG-6 →	+0.082	+1.554	<.001	<.001	3	3
UCEC	Caspase-7-cleavedD198 →	+0.564	+1.777	<.001	.001	3	3
LIHC	Smac →	-0.233	-3.153	.025	.018	3	2
COAD	G6PD →	+0.134	+1.457	.005	.010	3	2
COAD	Lck →	+0.237	+1.347	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 65 associations by consensus.

TIGAR by UNC80 expression — UCEC

Explore this box plot interactively →