UNC80

Across TCGA cell cohorts, UNC80 mutation is significantly associated with the RNA expression of many other genes, with 1,501 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UNC80-associated genes across cancer lineages are LYG1, SGCB, and ZNF286A. Each is linked with UNC80 in more than 3 cancer types. Because this analysis shows association rather than direction, both UNC80-to-partner and partner-to-UNC80 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LYG1 grouped by UNC80-low versus UNC80-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UNC80→partner) and Y-score (partner→UNC80) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LYG1 →	+0.758	+1.808	<.001	.001	3	4
LARGE_INTESTINE	SGCB →	+1.236	+3.364	<.001	<.001	3	3
BLOOD_Leukemia	ZNF286A →	+1.226	+3.518	<.001	<.001	3	3
LARGE_INTESTINE	ACBD5 →	+0.838	+3.584	<.001	<.001	3	3
LARGE_INTESTINE	NCOR1 →	+0.723	+1.871	.002	.002	3	3
LARGE_INTESTINE	SMARCA5 →	+0.513	+3.459	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,501 associations by consensus.

LYG1 by UNC80 expression — LARGE_INTESTINE

Explore this box plot interactively →