UNC5B

Across TCGA pan-cancer cohorts, UNC5B mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated UNC5B data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher UNC5B mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated UNC5B expression acts as an unfavorable survival marker, although some lineages such as CCRCC and UCEC show a favorable association.

PDAC, CCRCC, and UCEC are the cancer types where UNC5B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	II,III,IV	0.594	0.833	.001	18	view →
CCRCC	OS	Median	III,IV	1.000	0.727	.016	18	view →
UCEC	OS	Median	II,III,IV	1.000	0.552	.006	16	view →
HNSC	DFS	Median	IV	0.784	0.523	.012	7	view →
LSCC	DFS	Median	All	0.626	0.778	.045	3	view →
LUAD	OS	Tertile	III,IV	0.547	0.788	.044	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

UNC5B–PDAC (DFS)

Open the PDAC breakdown →