UNC5A

Across TCGA pan-cancer cohorts, UNC5A Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated UNC5A data layer compared with 20 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in sarcoma (SARC), where higher UNC5A Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated UNC5A expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

SARC, PRAD, and ESCA are the cancer types where UNC5A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SARC	DFS	Median	All	0.159	0.613	.015	6	view →
PRAD	DFS	Median	All	0.107	0.886	<.001	6	view →
ESCA	DFS	Median	II,III,IV	0.200	0.525	.038	6	view →
UCEC	DFS	Median	All	0.973	0.828	.023	6	view →
SKCM	DFS	Median	II,III,IV	0.846	0.539	.017	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

UNC5A–SARC (DFS)

Open the SARC breakdown →