UNC5A

Across TCGA patient cohorts, UNC5A mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UNC5A-associated genes across cancer lineages are 4E-BP1_pS65, eIF4G, and Notch1. Each is linked with UNC5A in more than 2 cancer types. Because this analysis shows association rather than direction, both UNC5A-to-partner and partner-to-UNC5A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1_pS65 grouped by UNC5A-low versus UNC5A-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UNC5A→partner) and Y-score (partner→UNC5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	4E-BP1_pS65 →	+0.164	+2.820	.023	.035	3	3
UCEC	eIF4G →	+0.226	+2.000	.039	.029	3	2
UCEC	Notch1 →	+0.122	+2.000	.014	.003	3	2
UCEC	p62 Lck ligand →	+0.358	+2.807	.001	.002	3	2
UCEC	PCNA →	+0.184	+1.874	.016	.049	3	2
UCEC	Annexin-1 →	+0.430	+2.019	.020	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

4E-BP1_pS65 by UNC5A expression — LUAD

Explore this box plot interactively →