UNC5A

Across TCGA cell cohorts, UNC5A RNA expression is significantly associated with the go_rna of many other GO terms, with 2,786 significant associations in total. BONE shows the largest number of these associations.

The most reproducible UNC5A-associated GO terms across cancer lineages are Regulation of B cell differentiation, Regulation of neuron projection regeneration, and Regulation of dense core granule exocytosis. Each is linked with UNC5A in more than 6 cancer types. Because this analysis shows association rather than direction, both UNC5A-to-partner and partner-to-UNC5A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of B cell differentiation grouped by UNC5A-low versus UNC5A-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (UNC5A→partner) and Y-score (partner→UNC5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Regulation of B cell differentiation →	-0.124	-1.645	.005	.002	3	7
BLOOD_Lymphoma	Regulation of neuron projection regeneration →	-0.096	-0.029	.001	.002	2	7
LUNG_SCLC	Regulation of dense core granule exocytosis →	+0.890	+1.923	<.001	<.001	3	6
OESOPHAGUS	Negative regulation of protein localization to ciliary membrane →	+0.120	+1.058	.001	.003	3	6
BONE	Nonassociative learning →	+1.506	+1.604	<.001	<.001	3	6
BLOOD_Leukemia	Aldehyde catabolic process →	+0.094	+0.114	<.001	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,786 associations by consensus.

Regulation of B cell differentiation by UNC5A expression — LUNG_SCLC

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