UNC50

Across TCGA cell cohorts, UNC50 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,936 significant associations in total. BONE shows the largest number of these associations.

The most reproducible UNC50-associated GO terms across cancer lineages are Protein demannosylation, Protein alpha-1,2-demannosylation, and Protein deglycosylation. Each is linked with UNC50 in more than 13 cancer types. Because this analysis shows association rather than direction, both UNC50-to-partner and partner-to-UNC50 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein demannosylation grouped by UNC50-low versus UNC50-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (UNC50→partner) and Y-score (partner→UNC50) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Protein demannosylation →	+0.150	+0.770	<.001	<.001	3	14
BONE	Protein alpha-1,2-demannosylation →	+0.150	+0.770	<.001	<.001	3	14
OESOPHAGUS	Protein deglycosylation →	+0.142	+0.960	<.001	<.001	3	13
BONE	Endoplasmic reticulum mannose trimming →	+0.139	+0.640	<.001	<.001	3	13
BONE	Response to topologically incorrect protein →	+0.091	+0.699	<.001	<.001	3	11
BLOOD_Myeloma	Cellular response to topologically incorrect protein →	+0.104	+1.004	.001	<.001	2	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,936 associations by consensus.

Protein demannosylation by UNC50 expression — BONE

Explore this box plot interactively →