UNC50

Across TCGA cell cohorts, UNC50 mutation is significantly associated with the mutation status of many other genes, with 207 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible UNC50-associated genes across cancer lineages are BMP10, ACSF3, and GYPE. Each is linked with UNC50 in more than 1 cancer types. Because this analysis shows association rather than direction, both UNC50-to-partner and partner-to-UNC50 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BMP10 grouped by UNC50-low versus UNC50-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UNC50→partner) and Y-score (partner→UNC50) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	BMP10 →	+4.415	+4.977	.007	.007	1	2
CNS	ACSF3 →	+5.044	+5.614	.003	.003	1	2
CNS	GYPE →	+5.044	+5.614	.003	.003	1	2
CNS	PPP6R2 →	+5.044	+5.614	.003	.003	1	1
CNS	GMPR2 →	+5.044	+5.614	.003	.003	1	1
CNS	USP14 →	+6.044	+6.044	.001	.001	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 207 associations by consensus.

BMP10 by UNC50 expression — OVARY

Explore this box plot interactively →