UNC45B

Across TCGA pan-cancer cohorts, UNC45B mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated UNC45B data layer compared with 24 for mass-spec protein and 11 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher UNC45B mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated UNC45B expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

LUAD, LSCC, and HNSC are the cancer types where UNC45B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.860	0.572	.010	4	view →
LSCC	OS	Quartile	All	0.944	0.727	.035	1	view →
HNSC	DFS	Median	III,IV	1.000	0.939	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

UNC45B–LUAD (OS)

Open the LUAD breakdown →