UNC45B

Across TCGA patient cohorts, UNC45B mutation is significantly associated with the RNA expression of many other genes, with 5,358 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UNC45B-associated genes across cancer lineages are HASPIN, HLTF, and GTSE1. Each is linked with UNC45B in more than 3 cancer types. Because this analysis shows association rather than direction, both UNC45B-to-partner and partner-to-UNC45B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HASPIN grouped by UNC45B-low versus UNC45B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UNC45B→partner) and Y-score (partner→UNC45B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HASPIN →	+0.788	+2.044	<.001	<.001	3	4
UCEC	HLTF →	+0.544	+2.513	.001	<.001	3	4
UCEC	GTSE1 →	+0.789	+2.344	<.001	<.001	3	4
LUAD	RAMP2 →	-0.614	-2.999	.003	.001	3	4
SKCM	RPL23AP82 →	+0.516	+3.969	<.001	<.001	3	4
COAD	GAS2L1 →	+0.605	+2.710	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,358 associations by consensus.

HASPIN by UNC45B expression — UCEC

Explore this box plot interactively →