UNC45B

Across TCGA patient cohorts, UNC45B mutation is significantly associated with the total protein of many other genes, with 67 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UNC45B-associated genes across cancer lineages are ATM, Caspase-7-cleavedD198, and JNK_pT183_Y185. Each is linked with UNC45B in more than 4 cancer types. Because this analysis shows association rather than direction, both UNC45B-to-partner and partner-to-UNC45B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by UNC45B-low versus UNC45B-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UNC45B→partner) and Y-score (partner→UNC45B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ATM →	-0.607	-2.576	<.001	.011	3	5
COAD	Caspase-7-cleavedD198 →	+1.033	+3.169	.001	.018	3	4
UCEC	JNK_pT183_Y185 →	-0.114	-1.188	.029	.028	3	3
SKCM	GAPDH →	+0.423	+2.321	.040	.032	3	3
SKCM	TAZ →	+0.145	+1.662	.009	.011	3	3
COAD	ACC_pS79 →	-0.302	-3.000	.016	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 67 associations by consensus.

ATM by UNC45B expression — COAD

Explore this box plot interactively →