UNC45B

Across TCGA cell cohorts, UNC45B RNA expression is significantly associated with the go_rna of many other GO terms, with 901 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible UNC45B-associated GO terms across cancer lineages are Regulation of mRNA stability, Promoter clearance during DNA-templated transcription, and RNA polymerase II promoter clearance. Each is linked with UNC45B in more than 3 cancer types. Because this analysis shows association rather than direction, both UNC45B-to-partner and partner-to-UNC45B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of mRNA stability grouped by UNC45B-low versus UNC45B-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (UNC45B→partner) and Y-score (partner→UNC45B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Regulation of mRNA stability →	+0.074	+1.315	<.001	.002	3	4
SOFT_TISSUE	Promoter clearance during DNA-templated transcription →	+0.151	+1.387	<.001	.001	3	3
SOFT_TISSUE	RNA polymerase II promoter clearance →	+0.151	+1.387	<.001	.001	3	3
LARGE_INTESTINE	Regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.093	+0.002	.004	.004	3	3
LARGE_INTESTINE	Stress granule assembly →	+0.092	+0.002	.004	.007	3	3
SOFT_TISSUE	mRNA transcription by RNA polymerase II →	+0.050	+0.727	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 901 associations by consensus.

Regulation of mRNA stability by UNC45B expression — SOFT_TISSUE

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