UNC45B

Across TCGA cell cohorts, UNC45B mutation is significantly associated with the RNA expression of many other genes, with 160 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UNC45B-associated genes across cancer lineages are BMP10, CCDC63, and ETHE1. Each is linked with UNC45B in more than 1 cancer types. Because this analysis shows association rather than direction, both UNC45B-to-partner and partner-to-UNC45B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BMP10 grouped by UNC45B-low versus UNC45B-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UNC45B→partner) and Y-score (partner→UNC45B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	BMP10 →	+0.476	+3.956	.001	<.001	3	2
BLOOD_Leukemia	CCDC63 →	+0.063	+3.634	.005	.002	3	2
LARGE_INTESTINE	ETHE1 →	+0.831	+3.386	.006	.001	3	2
LARGE_INTESTINE	EAPP →	+0.425	+2.502	.003	.005	3	2
LARGE_INTESTINE	CASP6 →	+0.851	+3.628	<.001	<.001	3	2
LARGE_INTESTINE	B3GNT4 →	+0.645	+3.169	.002	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 160 associations by consensus.

BMP10 by UNC45B expression — BLOOD_Leukemia

Explore this box plot interactively →