UNC13D

Across TCGA pan-cancer cohorts, UNC13D Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated UNC13D data layer compared with 29 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher UNC13D Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated UNC13D expression acts as an unfavorable survival marker, although some lineages such as BLCA show a favorable association.

KIRC, KIRP, and CESC are the cancer types where UNC13D Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.180	0.796	.001	18	view →
KIRP	OS	Median	All	0.683	0.950	<.001	7	view →
CESC	OS	Median	II,III,IV	0.203	0.759	.021	6	view →
PRAD	OS	Median	All	0.572	0.883	<.001	6	view →
SKCM	DFS	Median	IV	0.040	0.454	.028	6	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →
BLCA	DFS	Median	All	0.854	0.607	.049	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

UNC13D–KIRC (DFS)

Open the KIRC breakdown →