UNC13D

Across TCGA pan-cancer cohorts, UNC13D mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated UNC13D data layer compared with 29 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher UNC13D mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated UNC13D expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

HNSC, LSCC, and CCRCC are the cancer types where UNC13D mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	All	0.897	0.562	.001	45	view →
LSCC	OS	Quartile	II,III,IV	0.567	1.000	.010	15	view →
CCRCC	OS	Median	IV	1.000	0.451	.016	7	view →
LUAD	OS	Quartile	II,III,IV	0.265	0.586	.020	7	view →
PDAC	OS	Median	II,III,IV	0.479	0.290	.037	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

UNC13D–HNSC (OS)

Open the HNSC breakdown →