UNC13D

Across TCGA patient cohorts, UNC13D mutation is significantly associated with the RNA expression of many other genes, with 3,686 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UNC13D-associated genes across cancer lineages are CNIH1, PLEKHB2, and YARS1. Each is linked with UNC13D in more than 3 cancer types. Because this analysis shows association rather than direction, both UNC13D-to-partner and partner-to-UNC13D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CNIH1 grouped by UNC13D-low versus UNC13D-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UNC13D→partner) and Y-score (partner→UNC13D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CNIH1 →	+0.465	+1.947	<.001	<.001	3	4
UCEC	PLEKHB2 →	+0.481	+3.130	<.001	<.001	3	4
STAD	YARS1 →	+0.498	+3.219	.008	.009	3	4
SKCM	SLC9A5 →	+0.724	+3.459	<.001	.005	3	4
STAD	GEMIN2 →	+0.478	+3.203	.001	.009	3	4
LIHC	EIF1P1 →	+0.232	+5.618	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,686 associations by consensus.

CNIH1 by UNC13D expression — UCEC

Explore this box plot interactively →