UNC13D

Across TCGA patient cohorts, UNC13D mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UNC13D-associated genes across cancer lineages are Rad50, ATM, and MSH2. Each is linked with UNC13D in more than 2 cancer types. Because this analysis shows association rather than direction, both UNC13D-to-partner and partner-to-UNC13D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by UNC13D-low versus UNC13D-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UNC13D→partner) and Y-score (partner→UNC13D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.263	-2.209	.002	.009	3	3
UCEC	ATM →	-0.412	-2.446	.010	.018	3	3
UCEC	MSH2 →	-0.234	-2.295	.004	.033	3	2
UCEC	Notch1 →	+0.138	+2.817	.005	.001	3	2
UCEC	PCNA →	+0.179	+1.662	.019	.011	3	2
UCEC	Caspase-7-cleavedD198 →	+0.821	+1.926	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Rad50 by UNC13D expression — UCEC

Explore this box plot interactively →