UNC13D

Across TCGA cell cohorts, UNC13D mutation is significantly associated with the RNA expression of many other genes, with 47 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible UNC13D-associated genes across cancer lineages are WDR87, KCNJ9, and OR8A1. Each is linked with UNC13D in more than 1 cancer types. Because this analysis shows association rather than direction, both UNC13D-to-partner and partner-to-UNC13D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WDR87 grouped by UNC13D-low versus UNC13D-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UNC13D→partner) and Y-score (partner→UNC13D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	WDR87 →	+0.497	+3.611	<.001	.006	3	2
BLOOD_Leukemia	KCNJ9 →	+0.043	+3.444	.001	.004	3	2
BONE	OR8A1 →	+0.090	+5.169	<.001	.004	3	1
LUNG_SCLC	SPRR2B →	+0.093	+5.169	<.001	<.001	3	1
BREAST	OR2M3 →	+0.006	+5.169	<.001	.005	3	1
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

WDR87 by UNC13D expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →