UNC13C

Across TCGA pan-cancer cohorts, UNC13C Mutation is linked to patient survival in 13 of 34 cancer types, making it a survival-associated UNC13C data layer compared with 21 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher UNC13C Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated UNC13C expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

UCEC, ACC, and LUSC are the cancer types where UNC13C Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.768	0.626	.003	24	view →
ACC	OS	Median	All	0.287	0.809	<.001	18	view →
LUSC	DFS	Median	III,IV	0.209	0.674	<.001	18	view →
SKCM	DFS	Median	II,III,IV	0.790	0.633	<.001	16	view →
ESCA	OS	Median	II,III,IV	0.103	0.868	<.001	12	view →
BLCA	DFS	Median	II,III,IV	0.711	0.317	.021	10	view →
OV	DFS	Median	IV	0.502	0.270	.013	8	view →
CHOL	OS	Median	III,IV	0.275	0.886	.045	6	view →
READ	OS	Median	IV	0.289	0.899	<.001	6	view →
PRAD	DFS	Median	All	0.689	0.937	.001	6	view →
LUAD	OS	Median	III,IV	0.075	0.672	<.001	6	view →
HNSC	OS	Median	IV	1.000	0.398	.039	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

UNC13C–UCEC (DFS)

Open the UCEC breakdown →