Across TCGA patient cohorts, UNC13B protein abundance is significantly associated with the RNA expression of many other genes, with 8,338 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible UNC13B-associated genes across cancer lineages are RGP1, GBA2, and IL2RA. Each is linked with UNC13B in more than 5 cancer types. Because this analysis shows association rather than direction, both UNC13B-to-partner and partner-to-UNC13B results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UNC13B→partner) and Y-score (partner→UNC13B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RGP1 →	+0.528	+0.224	<.001	<.001	3	6
HNSC	GBA2 →	+0.751	+0.204	<.001	.005	3	6
BRCA	IL2RA →	-1.005	-0.490	<.001	<.001	3	5
BRCA	RASEF →	+0.970	+0.418	.006	<.001	3	5
LSCC	TMEM125 →	+1.390	+0.433	<.001	<.001	3	5
UCEC	C9orf152 →	+1.445	+0.313	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,338 associations by consensus.

Exploration

UNC13B survival (RNA) · tumor vs normal (RNA) · all UNC13B data types