Across TCGA patient cohorts, UNC13B mutation is significantly associated with the RNA expression of many other genes, with 5,443 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UNC13B-associated genes across cancer lineages are LONP1, EMC6, and ENO1. Each is linked with UNC13B in more than 3 cancer types. Because this analysis shows association rather than direction, both UNC13B-to-partner and partner-to-UNC13B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UNC13B→partner) and Y-score (partner→UNC13B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LONP1 →	+0.624	+2.565	<.001	<.001	3	4
SKCM	EMC6 →	+0.490	+2.594	.005	.006	3	4
COAD	ENO1 →	+0.581	+3.740	<.001	<.001	3	4
UCEC	NCAPG →	+0.667	+1.425	<.001	<.001	3	4
UCEC	CHAF1A →	+0.641	+1.862	<.001	<.001	3	4
SKCM	C16orf95 →	+0.561	+2.816	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,443 associations by consensus.

Exploration

UNC13B survival (RNA) · tumor vs normal (RNA) · all UNC13B data types