Across TCGA patient cohorts, UNC13B mutation is significantly associated with the total protein of many other genes, with 62 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UNC13B-associated genes across cancer lineages are 4E-BP1, EGFR_pY1068, and FASN. Each is linked with UNC13B in more than 3 cancer types. Because this analysis shows association rather than direction, both UNC13B-to-partner and partner-to-UNC13B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UNC13B→partner) and Y-score (partner→UNC13B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.295	+2.523	<.001	<.001	3	4
UCEC	EGFR_pY1068 →	-0.153	-0.956	.017	.023	3	3
COAD	FASN →	+0.448	+2.593	.006	.006	3	3
COAD	Rad50 →	-0.361	-3.000	<.001	.034	3	3
COAD	Caspase-7-cleavedD198 →	+1.098	+3.338	<.001	.004	3	3
COAD	CD49b →	+0.344	+2.824	.005	.034	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 62 associations by consensus.

Exploration

UNC13B survival (RNA) · tumor vs normal (RNA) · all UNC13B data types