UMPS

Across TCGA pan-cancer cohorts, UMPS mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated UMPS data layer compared with 22 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher UMPS mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated UMPS expression acts as an unfavorable survival marker, although some lineages such as PDAC and LSCC show a favorable association.

PDAC, LSCC, and LUAD are the cancer types where UMPS mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	All	0.669	0.432	.035	8	view →
LSCC	DFS	Median	All	0.975	0.895	.030	5	view →
LUAD	OS	Tertile	All	0.962	0.578	.007	3	view →
CCRCC	DFS	Tertile	All	0.595	0.851	.018	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

UMPS–PDAC (OS)

Open the PDAC breakdown →