Across TCGA patient cohorts, UMAD1 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UMAD1-associated genes across cancer lineages are JNK_pT183_Y185, Tuberin, and 53BP1. Each is linked with UMAD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both UMAD1-to-partner and partner-to-UMAD1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UMAD1→partner) and Y-score (partner→UMAD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.243	-2.986	.012	.037	3	1
UCEC	Tuberin →	+0.372	+2.817	.016	.036	3	1
UCEC	53BP1 →	+0.476	+3.000	.016	.037	3	1
UCEC	C-Raf_pS338 →	-0.133	-2.950	.005	.036	2	1
UCEC	EGFR_pY1068 →	-0.332	-3.000	.022	.037	1	1
UCEC	p62 Lck ligand →	+0.663	+3.000	<.001	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Exploration

UMAD1 survival (RNA) · tumor vs normal (RNA) · all UMAD1 data types