ULK4

Across TCGA cell cohorts, ULK4 mutation is significantly associated with the RNA expression of many other genes, with 41 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ULK4-associated genes across cancer lineages are PRR27, OR14A16, and C12orf40. Each is linked with ULK4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ULK4-to-partner and partner-to-ULK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRR27 grouped by ULK4-low versus ULK4-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ULK4→partner) and Y-score (partner→ULK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PRR27 →	+0.139	+4.256	.001	.002	3	2
BLOOD_Lymphoma	OR14A16 →	+0.013	+4.058	<.001	.009	3	2
OVARY	C12orf40 →	+0.012	+3.444	<.001	.003	3	2
STOMACH	DGAT2L6 →	+0.144	+3.432	.001	.008	3	2
CNS	NOBOX →	+0.025	+5.321	<.001	.005	3	1
CNS	CYLC2 →	+0.016	+5.321	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

PRR27 by ULK4 expression — LUNG_SCLC

Explore this box plot interactively →