ULK3

Across TCGA pan-cancer cohorts, ULK3 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ULK3 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher ULK3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ULK3 expression acts as an unfavorable survival marker, although some lineages such as LSCC and UCEC show a favorable association.

LSCC, UCEC, and GBM are the cancer types where ULK3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	All	0.947	0.698	.002	43	view →
UCEC	DFS	Median	II,III,IV	0.924	0.431	.006	24	view →
GBM	OS	Quartile	All	0.246	0.696	<.001	13	view →
CCRCC	DFS	Median	II,III,IV	0.780	0.495	.027	10	view →
PDAC	OS	Quartile	All	0.360	0.673	.016	4	view →
LUAD	OS	Quartile	All	0.593	0.983	.038	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ULK3–LSCC (DFS)

Open the LSCC breakdown →