ULK3

Across TCGA patient cohorts, ULK3 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ULK3-associated genes across cancer lineages are Notch1, TIGAR, and ATM. Each is linked with ULK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ULK3-to-partner and partner-to-ULK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by ULK3-low versus ULK3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ULK3→partner) and Y-score (partner→ULK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.148	+1.750	.008	.049	3	2
UCEC	TIGAR →	+0.146	+2.441	.017	.001	3	2
UCEC	ATM →	-0.612	-2.415	<.001	.003	3	2
UCEC	eIF4E →	+0.245	+2.598	.003	.005	3	1
UCEC	IGFBP2 →	-0.771	-3.321	.003	.009	3	1
UCEC	MEK1 →	+0.430	+2.222	.003	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Notch1 by ULK3 expression — UCEC

Explore this box plot interactively →