ULK2

Across TCGA patient cohorts, ULK2 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ULK2-associated genes across cancer lineages are ATM, PKC-a, and Rad50. Each is linked with ULK2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ULK2-to-partner and partner-to-ULK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ULK2-low versus ULK2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ULK2→partner) and Y-score (partner→ULK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ATM →	-0.430	-3.000	.011	.034	3	3
COAD	PKC-a →	-0.280	-3.000	.022	.034	3	2
COAD	Rad50 →	-0.322	-3.000	.002	.034	3	2
COAD	ASNS →	+0.670	+2.321	<.001	.033	3	2
UCEC	4E-BP1 →	+0.326	+2.906	<.001	.001	3	2
UCEC	C-Raf →	+0.166	+1.765	<.001	.013	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

ATM by ULK2 expression — COAD

Explore this box plot interactively →