ULK1

Across TCGA pan-cancer cohorts, ULK1 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated ULK1 data layer compared with 25 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher ULK1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ULK1 expression acts as an unfavorable survival marker, although some lineages such as BLCA and STAD show a favorable association.

LUAD, BLCA, and STAD are the cancer types where ULK1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	III,IV	0.153	0.660	.009	12	view →
BLCA	DFS	Median	II,III,IV	0.938	0.605	.019	10	view →
STAD	OS	Median	IV	0.805	0.283	.031	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →
SKCM	OS	Median	II,III,IV	0.409	0.738	.023	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

ULK1–LUAD (OS)

Open the LUAD breakdown →