ULK1

Across TCGA pan-cancer cohorts, ULK1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ULK1 data layer compared with 25 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ULK1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ULK1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

HNSC, LSCC, and GBM are the cancer types where ULK1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.993	0.907	.012	10	view →
LSCC	DFS	Median	II,III,IV	1.000	0.843	.011	7	view →
GBM	DFS	Median	All	0.452	0.296	.034	2	view →
LUAD	DFS	Median	II,III,IV	0.906	0.786	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ULK1–HNSC (DFS)

Open the HNSC breakdown →