ULK1

Across TCGA patient cohorts, ULK1 mutation is significantly associated with the RNA expression of many other genes, with 2,576 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ULK1-associated genes across cancer lineages are RAD51, PIMREG, and RN7SL131P. Each is linked with ULK1 in more than 4 cancer types. Because this analysis shows association rather than direction, both ULK1-to-partner and partner-to-ULK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RAD51 grouped by ULK1-low versus ULK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ULK1→partner) and Y-score (partner→ULK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RAD51 →	+0.652	+2.917	<.001	<.001	3	4
STAD	PIMREG →	+0.929	+3.338	.001	.005	2	5
READ	RN7SL131P →	+0.297	+5.421	<.001	.005	3	3
UCEC	CCDC3 →	-0.644	-1.836	.004	.001	3	3
UCEC	EME1 →	+0.444	+2.126	.004	<.001	3	3
UCEC	NRG2 →	-0.435	-2.372	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,576 associations by consensus.

RAD51 by ULK1 expression — UCEC

Explore this box plot interactively →