ULK1

Across TCGA cell cohorts, ULK1 mutation is significantly associated with the RNA expression of many other genes, with 274 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ULK1-associated genes across cancer lineages are BBS7, NUF2, and PPP4R2. Each is linked with ULK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ULK1-to-partner and partner-to-ULK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BBS7 grouped by ULK1-low versus ULK1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ULK1→partner) and Y-score (partner→ULK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BBS7 →	+0.521	+3.234	.007	.004	3	2
LARGE_INTESTINE	NUF2 →	+0.459	+2.502	.009	.005	3	2
LARGE_INTESTINE	PPP4R2 →	+0.459	+3.628	.006	<.001	3	2
UPPER_AERODIGESTIVE_TRACT	MTRNR2L6 →	+0.130	+4.357	<.001	.006	3	2
LUNG_SCLC	IL3 →	+0.055	+5.029	<.001	.006	3	1
LUNG_SCLC	PRAMEF10 →	+1.180	+5.643	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 274 associations by consensus.

BBS7 by ULK1 expression — LARGE_INTESTINE

Explore this box plot interactively →