ULBP2

Across TCGA pan-cancer cohorts, ULBP2 RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of ULBP2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ULBP2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ULBP2 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, COAD, and KIRC are the cancer types where ULBP2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ULBP2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+3.361	<.001	12	view →
COAD	Male	III,IV	+2.454	<.001	12	view →
KIRC	Male	All	+0.968	<.001	11	view →
BLCA	Male	III,IV	+3.941	<.001	10	view →
THCA	Female	III,IV	+1.935	<.001	9	view →
KICH	All	II,III,IV	−0.875	<.001	7	view →
LUSC	Male	All	+1.796	<.001	6	view →
UCEC	All	III,IV	+1.710	.001	6	view →
READ	All	All	+1.368	<.001	6	view →
BRCA	Female	II,III,IV	+0.696	<.001	6	view →
STAD	Male	All	+1.835	<.001	5	view →
LIHC	Female	II,III,IV	+0.759	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

ULBP2–HNSC

Open the HNSC breakdown →