UIMC1

Across TCGA pan-cancer cohorts, UIMC1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated UIMC1 data layer compared with 27 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher UIMC1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated UIMC1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and GBM show a favorable association.

LUAD, PDAC, and GBM are the cancer types where UIMC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Quartile	All	0.836	0.372	.002	43	view →
PDAC	OS	Median	II,III,IV	0.427	0.605	.001	17	view →
GBM	OS	Quartile	All	0.506	0.268	.014	4	view →
LSCC	OS	Median	All	0.820	0.938	.022	3	view →
HNSC	DFS	Quartile	III,IV	0.860	1.000	.017	3	view →
UCEC	OS	Tertile	All	0.845	0.971	.045	2	view →
CCRCC	DFS	Tertile	II,III,IV	0.774	0.461	.017	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

UIMC1–LUAD (DFS)

Open the LUAD breakdown →