UHRF2

Across TCGA pan-cancer cohorts, UHRF2 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated UHRF2 data layer compared with 27 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher UHRF2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated UHRF2 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

STAD, HNSC, and THYM are the cancer types where UHRF2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Median	All	0.223	0.669	.010	15	view →
HNSC	OS	Median	All	0.179	0.769	<.001	15	view →
THYM	DFS	Median	All	0.174	0.759	.028	9	view →
LIHC	OS	Median	All	0.083	0.783	<.001	9	view →
UCEC	DFS	Median	All	0.939	0.601	.010	8	view →
BRCA	DFS	Median	All	0.294	0.903	<.001	6	view →
COAD	OS	Median	All	0.654	0.875	.015	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

UHRF2–STAD (OS)

Open the STAD breakdown →