UHRF2

Across TCGA pan-cancer cohorts, UHRF2 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated UHRF2 data layer compared with 27 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher UHRF2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated UHRF2 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

CCRCC, PDAC, and HNSC are the cancer types where UHRF2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	III,IV	0.868	0.566	.005	41	view →
PDAC	DFS	Median	II,III,IV	0.278	0.481	.001	39	view →
HNSC	DFS	Quartile	All	0.696	0.947	<.001	25	view →
LUAD	DFS	Tertile	All	0.974	0.819	.009	11	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

UHRF2–CCRCC (DFS)

Open the CCRCC breakdown →