UHRF2

Across TCGA pan-cancer cohorts, UHRF2 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of UHRF2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where UHRF2 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types UHRF2 is over-expressed in tumor, although a few such as LUAD and PDAC show the opposite, repressed pattern.

HNSC, LUAD, and PDAC are the cancer types where UHRF2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UHRF2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+0.349	<.001	11	view →
LUAD	Female	All	−0.180	<.001	6	view →
PDAC	Female	All	−0.322	.019	2	view →
CCRCC	All	All	+0.079	.016	2	view →
LSCC	All	All	+0.095	.018	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

UHRF2–HNSC

Open the HNSC breakdown →