UHRF2

Across TCGA patient cohorts, UHRF2 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UHRF2-associated genes across cancer lineages are ATM, Annexin-1, and EGFR_pY1068. Each is linked with UHRF2 in more than 3 cancer types. Because this analysis shows association rather than direction, both UHRF2-to-partner and partner-to-UHRF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by UHRF2-low versus UHRF2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UHRF2→partner) and Y-score (partner→UHRF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.395	-2.000	.007	<.001	3	4
UCEC	Annexin-1 →	+0.561	+2.434	.001	.001	3	3
UCEC	EGFR_pY1068 →	-0.272	-2.321	<.001	<.001	3	2
UCEC	VHL →	-0.704	-1.440	.001	.022	3	2
UCEC	4E-BP1 →	+0.225	+3.700	.010	.001	3	2
COAD	Rad50 →	-0.248	-2.991	.048	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

ATM by UHRF2 expression — UCEC

Explore this box plot interactively →