UHRF2

Across TCGA cell cohorts, UHRF2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,371 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible UHRF2-associated GO terms across cancer lineages are Negative regulation of gene expression via chromosomal CpG island methylation, Regulation of sister chromatid cohesion, and Spindle assembly. Each is linked with UHRF2 in more than 16 cancer types. Because this analysis shows association rather than direction, both UHRF2-to-partner and partner-to-UHRF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of gene expression via chromosomal CpG island methylation grouped by UHRF2-low versus UHRF2-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (UHRF2→partner) and Y-score (partner→UHRF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Negative regulation of gene expression via chromosomal CpG island methylation →	+0.150	+1.153	<.001	<.001	3	17
OVARY	Regulation of sister chromatid cohesion →	+0.101	+0.793	<.001	<.001	3	14
LARGE_INTESTINE	Spindle assembly →	+0.071	+0.864	<.001	<.001	3	13
LUNG_SCLC	Protein sumoylation →	+0.087	+1.031	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Microtubule organizing center organization →	+0.100	+1.515	<.001	<.001	3	12
SOFT_TISSUE	Subtelomeric heterochromatin formation →	+0.100	+0.570	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,371 associations by consensus.

Negative regulation of gene expression via chromosomal CpG island methylation by UHRF2 expression — LUNG_SCLC

Explore this box plot interactively →