UHRF2

Across TCGA cell cohorts, UHRF2 mutation is significantly associated with the RNA expression of many other genes, with 218 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UHRF2-associated genes across cancer lineages are TAFA1, RBFA, and USP14. Each is linked with UHRF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both UHRF2-to-partner and partner-to-UHRF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAFA1 grouped by UHRF2-low versus UHRF2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UHRF2→partner) and Y-score (partner→UHRF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TAFA1 →	+1.057	+4.149	<.001	.003	3	2
LARGE_INTESTINE	RBFA →	+0.847	+3.364	<.001	.002	3	1
LARGE_INTESTINE	USP14 →	+0.659	+3.087	.003	.006	3	1
LARGE_INTESTINE	CLUAP1 →	+0.644	+3.252	.003	.002	3	1
LARGE_INTESTINE	UBXN8 →	+0.972	+3.364	<.001	.002	3	1
LARGE_INTESTINE	SH3GL2 →	+1.269	+3.667	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 218 associations by consensus.

TAFA1 by UHRF2 expression — BLOOD_Leukemia

Explore this box plot interactively →