UHRF1

Across TCGA pan-cancer cohorts, UHRF1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated UHRF1 data layer compared with 26 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher UHRF1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated UHRF1 expression acts as an unfavorable survival marker.

OV, COAD, and UCEC are the cancer types where UHRF1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	OS	Median	II,III,IV	0.021	0.844	<.001	36	view →
COAD	OS	Median	III,IV	0.163	0.699	.002	11	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →
SKCM	DFS	Median	III,IV	0.015	0.648	<.001	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

UHRF1–OV (OS)

Open the OV breakdown →