UHRF1

Across TCGA pan-cancer cohorts, UHRF1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated UHRF1 data layer compared with 26 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher UHRF1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated UHRF1 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

PDAC, COAD, and LSCC are the cancer types where UHRF1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	II,III,IV	0.549	0.961	<.001	67	view →
COAD	DFS	Tertile	II,III,IV	0.889	1.000	.020	36	view →
LSCC	DFS	Median	All	0.826	0.605	.005	21	view →
CCRCC	OS	Median	II,III,IV	0.760	1.000	.008	16	view →
HNSC	OS	Median	All	0.790	0.905	.015	7	view →
OV	DFS	Median	All	0.868	1.000	.040	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

UHRF1–PDAC (OS)

Open the PDAC breakdown →