UHMK1

Across TCGA pan-cancer cohorts, UHMK1 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated UHMK1 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher UHMK1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated UHMK1 expression acts as an unfavorable survival marker.

HNSC, THYM, and UVM are the cancer types where UHMK1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.069	0.768	<.001	24	view →
THYM	DFS	Median	III,IV	0.205	0.774	.007	15	view →
UVM	OS	Median	All	0.248	0.769	.007	12	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
COAD	OS	Median	All	0.214	0.675	.029	4	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

UHMK1–HNSC (OS)

Open the HNSC breakdown →