UHMK1

Across TCGA patient cohorts, UHMK1 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UHMK1-associated genes across cancer lineages are ERK2, INPP4B, and p21. Each is linked with UHMK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both UHMK1-to-partner and partner-to-UHMK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by UHMK1-low versus UHMK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UHMK1→partner) and Y-score (partner→UHMK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.181	+2.459	.019	.018	3	1
UCEC	INPP4B →	-0.277	-3.321	.033	.009	3	1
UCEC	p21 →	+0.173	+1.750	.025	.049	3	1
UCEC	p62 Lck ligand →	+0.281	+3.594	.032	.001	3	1
UCEC	Shc_pY317 →	-0.175	-1.906	.004	.016	3	1
UCEC	STAT5a →	+0.412	+3.321	.010	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

ERK2 by UHMK1 expression — UCEC

Explore this box plot interactively →