UHMK1

Across TCGA cell cohorts, UHMK1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,664 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible UHMK1-associated GO terms across cancer lineages are Protein deubiquitination, Regulation of maintenance of sister chromatid cohesion, and Regulation of maintenance of mitotic sister chromatid cohesion. Each is linked with UHMK1 in more than 11 cancer types. Because this analysis shows association rather than direction, both UHMK1-to-partner and partner-to-UHMK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein deubiquitination grouped by UHMK1-low versus UHMK1-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (UHMK1→partner) and Y-score (partner→UHMK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Protein deubiquitination →	+0.048	+0.858	<.001	<.001	3	12
BLOOD_Myeloma	Regulation of maintenance of sister chromatid cohesion →	+0.087	+1.166	.005	.002	3	12
BLOOD_Myeloma	Regulation of maintenance of mitotic sister chromatid cohesion →	+0.087	+1.166	.005	.002	3	12
LUNG_NSCLC_LUSC	Positive regulation of organelle assembly →	+0.057	+0.898	.007	.002	3	12
LARGE_INTESTINE	Endosomal transport →	+0.047	+0.652	.002	.005	3	11
OVARY	Negative regulation of microtubule depolymerization →	+0.125	+0.714	<.001	.005	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,664 associations by consensus.

Protein deubiquitination by UHMK1 expression — BLOOD_Leukemia

Explore this box plot interactively →