UGT3A2

Across TCGA patient cohorts, UGT3A2 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UGT3A2-associated genes across cancer lineages are PRDX1, mTOR, and Notch1. Each is linked with UGT3A2 in more than 2 cancer types. Because this analysis shows association rather than direction, both UGT3A2-to-partner and partner-to-UGT3A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRDX1 grouped by UGT3A2-low versus UGT3A2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UGT3A2→partner) and Y-score (partner→UGT3A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PRDX1 →	+0.287	+3.000	.048	.036	3	3
UCEC	mTOR →	-0.192	-2.115	.001	.017	3	3
UCEC	Notch1 →	+0.138	+1.884	.010	.030	3	3
UCEC	Cyclin-B1 →	+0.595	+2.087	.005	.005	3	3
LUAD	Bim →	+0.396	+3.000	.010	.036	3	2
SKCM	Src →	-0.149	-1.459	.046	.011	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

PRDX1 by UGT3A2 expression — LUAD

Explore this box plot interactively →