UGT3A2

Across TCGA cell cohorts, UGT3A2 mutation is significantly associated with the RNA expression of many other genes, with 91 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UGT3A2-associated genes across cancer lineages are RBMY1E, TRPV4, and STAB2. Each is linked with UGT3A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both UGT3A2-to-partner and partner-to-UGT3A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RBMY1E grouped by UGT3A2-low versus UGT3A2-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UGT3A2→partner) and Y-score (partner→UGT3A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	RBMY1E →	+0.820	+4.643	.002	.008	3	1
SKIN	TRPV4 →	+1.492	+2.588	.009	.004	3	1
SKIN	STAB2 →	+0.456	+2.502	.001	.005	3	1
SKIN	HSPBAP1 →	-0.460	-3.541	.002	.001	3	1
SKIN	KRTAP4-6 →	+0.013	+2.678	.001	.005	3	1
SKIN	PRAMEF33 →	+0.006	+2.678	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 91 associations by consensus.

RBMY1E by UGT3A2 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →