UGT3A1

Across TCGA patient cohorts, UGT3A1 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UGT3A1-associated genes across cancer lineages are FOXO3a_pS318_S321, Tuberin, and MEK1. Each is linked with UGT3A1 in more than 2 cancer types. Because this analysis shows association rather than direction, both UGT3A1-to-partner and partner-to-UGT3A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by UGT3A1-low versus UGT3A1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UGT3A1→partner) and Y-score (partner→UGT3A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	FOXO3a_pS318_S321 →	-0.118	-3.459	.019	.005	2	3
UCEC	Tuberin →	+0.373	+1.925	<.001	.005	3	2
UCEC	MEK1 →	+0.354	+2.321	.007	.001	3	2
UCEC	PR →	-0.196	-1.874	.030	.049	3	2
UCEC	ASNS →	+0.449	+1.906	<.001	.015	3	2
UCEC	Caspase-7-cleavedD198 →	+0.551	+2.019	.009	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

FOXO3a_pS318_S321 by UGT3A1 expression — LUAD

Explore this box plot interactively →