UGT3A1

Across TCGA cell cohorts, UGT3A1 mutation is significantly associated with the RNA expression of many other genes, with 164 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UGT3A1-associated genes across cancer lineages are OR5T2, GH2, and H4C7. Each is linked with UGT3A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both UGT3A1-to-partner and partner-to-UGT3A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5T2 grouped by UGT3A1-low versus UGT3A1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UGT3A1→partner) and Y-score (partner→UGT3A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OR5T2 →	+0.012	+4.058	<.001	.007	3	2
URINARY_TRACT	GH2 →	+0.030	+5.087	<.001	.004	3	1
URINARY_TRACT	H4C7 →	+0.163	+5.087	<.001	.004	3	1
PANCREAS	OR1L6 →	+0.019	+5.000	<.001	.006	3	1
CNS	HELT →	+0.027	+4.321	<.001	.009	3	1
LUNG_SCLC	AICDA →	+0.078	+3.898	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 164 associations by consensus.

OR5T2 by UGT3A1 expression — LUNG_SCLC

Explore this box plot interactively →